That left us with 1,886 companies. While tourism remains one of the most important industries contributing a major portion to the economy of Florida, several industries have grown over time.. From different food services to healthcare to consumer goods, here are the top 15 profit-making businesses you can do in Florida. Explore the list for more on the Florida companies, industries, and cities that are thriving most. Florida is a well-known state of the United States of America with a total population of around 21.31 million. It's not one of these … 1 - 10 of 250. We then ranked each company from most to least current employees to determine the biggest companies in Florida. PAGE GO. The Florida 500 is a special section highlighting the 500 most influential executives in different economic sectors across the state. As it turns out, Publix looks to the be the biggest company in Florida clocking in with 191,000 employees. According to a public-private partnership named Enterprise Florida, the state has a great reputation for being America’s one of the most friendly states for starting small businesses. Now, check out how the 100 biggest companies in Florida ranked. This immense, year-long research initiative by the editors of Florida Trend has resulted in a personal, engaging look at Florida's most influential business leaders. Nineteen Southwest Florida firms made Inc. magazine's inaugural 2020 list of the state's 250 most successful companies. There are a number of businesses you can start in Florida which has immense potential to grow country-wide.